Cart
sales@molnova.com
Home - Products - GPCR/G Protein - Histamine Receptor - JNJ 39220675

JNJ 39220675

CAS No. 959740-39-7

JNJ 39220675 ( JNJ39220675;JNJ-39220675 )

Catalog No. M16848 CAS No. 959740-39-7

JNJ 39220675 is potent and selective, brain penetrant H3 antagonist with Ki of 1.4 nM, pA2 of 9.42 for hH3.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 873 Get Quote
50MG 1782 Get Quote
100MG 2250 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    JNJ 39220675
  • Note
    Research use only, not for human use.
  • Brief Description
    JNJ 39220675 is potent and selective, brain penetrant H3 antagonist with Ki of 1.4 nM, pA2 of 9.42 for hH3.
  • Description
    JNJ 39220675 is potent and selective, brain penetrant H3 antagonist with Ki of 1.4 nM, pA2 of 9.42 for hH3; dose-dependently reduces both alcohol intake and preference in alcohol-preferring rats, reduces alcohol self-administration without changing saccharin self-administration in alcohol non-dependent rats.Other Indication Phase 2 Discontinued
  • Synonyms
    JNJ39220675;JNJ-39220675
  • Pathway
    GPCR/G Protein
  • Target
    Histamine Receptor
  • Recptor
    Histamine Receptor
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    959740-39-7
  • Formula Weight
    369.44
  • Molecular Formula
    C21H24FN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(N1CCCN(C2CCC2)CC1)c3cnc(Oc4ccc(F)cc4)cc3
  • Chemical Name
    (4-cyclobutyl-1,4-diazepan-1-yl)(6-(4-fluorophenoxy)pyridin-3-yl)methanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Letavic MA, et al. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4210-4.
2. Galici R, et al. Psychopharmacology (Berl). 2011 Apr;214(4):829-41.
3. Nuutinen S, et al. Neuropharmacology. 2016 Jul;106:156-63.
4. Vanhanen J, et al. Br J Pharmacol. 2013 Sep;170(1):177-87.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • GSK-239512

    GSK-239512 is an antagonist of H3 receptor and can be used in studies about the treatment of cognitive dysfunction in neurodegenerative disorders.

  • T56-LIMKi

    T56-LIMKi is a selective inhibitor of LIMK2.

  • Tecastemizole

    Tecastemizole is a selective antagonist of H1 receptor and a major metabolite of astemizole with anti-inflammatory effects.

Sign In Join Free